By Muliere P., Petrone S.
His paper appears to be like at a brand new method of the matter of discovering the maximal tolerated dose (or optimum dose, Eichhorn and Zacks, 1973) of convinced medications which as well as their healing results have secondary damaging effects.The challenge is investigated in a sequential surroundings from a Bayesian predictive process. seek strategies are proposed for parametric and nonparametric types.
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Extra info for A bayesian predictive approach to sequential search for an optimal dose: Parametric and nonparametric
Preparation from 3,5-diacetoxyacetophenone by hydrolysis with 10% sulfuric acid at reflux (41%) . The starting ketone was prepared by reaction of methyl bromide on the 3,5-diacetoxybenzoyl chloride in the presence of dimethyl cadmium. p. 148° , 147-148° ; Spectra (NA). wt. 15 Syntheses -Preparation by Fries rearrangement of pyrogallol triacetate with aluminium chloride without solvent [415,419], (very good yield) . -Preparation by reaction of acetic anhydride on the pyrogallol, *with Amberlite IR-120 or Zeokarb 225, at 160° (84%) ; *with few drops sulfuric acid at 130° (65%) ; *with zinc chloride at 145-150° (53%)  or in the presence of acetic acid (58-63%) [99,612]; *with sulfuric acid and benzene-1,3-disulfonic acid mixture at 135° (54%) ; *with 70% perchloric acid on a steam bath (44%) .
Wt. 15 Synthesis -Refer to , (compound NP). p. and Spectra (NA). wt. 15 Syntheses -Preparation by nitration of 4-hydroxyacetophenone [128,147,213,460,533,801,1161,1475], (85%) [460,1475], (70-75%) [147,533,1161], (56%) . -Preparation by reaction of acetyl chloride on the 2-nitrophenol with aluminium chloride in nitrobenzene (46-47%) [233,283,746,1198]. -Obtained by reaction of acetyl chloride on the 2-nitroanisole with aluminium chloride (11%) . -Preparation by Fries rearrangement of 2-nitrophenyl acetate with aluminium chloride in nitrobenzene (40-45%) [558,746], (30%) [233,1410].
Karst) . -Obtained by saponification of Apiin or Apigenin with boiling 25% aqueous sodium hydroxide (87%) . Apiin or 4',5,7-trihydroxyflavone-7-apiosylglucoside was isolated from parsley or from celery [1504,1505]. p. p. 3 147-148° ; 1 H NMR [211,442,1110,1123], 13C NMR , IR [801,821,1110], UV [269,801,863,925,926,930,1014,1110,1441]; pK A [801,1387,1538]. wt. 22 Synthesis -Preparation by reaction of stannous chloride with the 2-acetyl-5-chlorosulfonylphenol in acetic acid previously saturated with gaseous hydrochloric acid (63%) .